In their three years stationed at Fort Irwin, they’ve traveled across states and southern California, he has been apart of his unit’s champion softball team and his children have flourished scholastically and socially. “When I found out that I was going to California as my first duty station, I talked to my wife and said‘we’re going to treat this like a vacation,” he said. He enlisted into the Army Reserve for six years, changed his military occupational specialty (MOS) from 19K to 88M, and will be able to work with the Customs and Border Protection and possibly transfer back to the United States.Ĭortes said he, his wife Ivelisse Espanol and his three daughters (17, 14 and seven years old) have enjoyed their time in Fort Irwin and now his family doesn’t want to leave. He also wants to return to complete his bachelor’s degree.īefore Cortes joined the Army, he was working with the Puerto Rican police department for about ten years. “The reason why I want to go back is because I want to be with them,” Quinones said. He will remain an 11B in the Puerto Rico National Guard for three years and is happy to return to his mother and sister. “Both soldiers are fine examples to the Fort Irwin community and the United States Army,” he said.īefore entering the military, Quinones worked with manufacturig prescription medication as an engineer. We’ve experienced so much together.”īuchmann shared their story with others who also thought it was pretty unique. “We came all the way together from Puerto Rico to Fort Irwin. Cortes I was going to reenlist and sign a contract with again,” he said. “That was pretty cool because when I get to the office, I found out it was Sgt. “So when we get there, I find out that the ‘other guy’ was Spc. Buchmann called me and said ‘hey Cortes, tomorrow, if you have time, we can do the reenlistment ceremony, and by the way, I have another guy that we’re going to reenlist,’” Cortes said. “I got both of them lined up for continued service in the Army Reserve and Puerto Rico Army National Guard.” Quinones was from the same town in Puerto Rico and was also interested in continuing his service,” Buchmann said. “I didn’t know at the time that his friend Spc. In March 2021, both Cortes reached out to Master Sgt. “We’re pretty much neighbors in the company.” “I’m at Dealer Company and he’s in Assassin Company,” Cortes said. They are both apart of the 11th Armored Cavalry Regiment as an 19K Tanker (Cortes) and 11B Infantry (Quinones) and said they get to chat everyday at work. Quinones arrived at Fort Irwin just two weeks before Cortes during the summer of 2018. They were in different basic training units in Fort Benning, so didn’t get to communicate much but Cortes said, “I remember, once I got out of basic, after graduation, I called him.” “We were talking about the ASVAB test because we didn’t think we were ready for the test…we tried to get calm and pass the test.” Quinones said they bonded during their first encounter because they tried to calm eachother. I remember he parked his car right next to mine.” “We went to the same recruiting office and they gave us an appointment and told us to be at the office early in the morning and we were the first two to get to the office,” Cortes said. The two recounted when they first met back in their home of Puerto Rico. “I told him I’m going to Fort Irwin, I just got done at Basic Training and he was like, wait, I’m here already!” “I remember, once I got out of basic (training), after graduation, I called him,” Cortes said. together, shipped to their first duty station of Fort Irwin together, and recently re-enlisted together with plans of both returning to their families in Puerto Rico…together. Hector Quinones, 31, enlisted together in Puerto Rico in 2018, took the Armed Services Vocational Aptitude Battery (ASVAP) and Military Entrance Processing Station tests together, went to basic training and advanced individual training (AIT) in Fort Benning, Ga. But two Army soldiers have somewhat defied the odds and been able to say “hello” and serve together throughout their entire service. When it comes to military service, you learn to say “goodbye” far too often, as you move every one to three years in many cases. Army) VIEW ORIGINAL 2 / 2 Show Caption + Hide Caption –įort Irwin soldiers are now friends headed back to their PR homes Hector Quinones saying their oath together in 20.
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In the first, Yadav and his team looked at the relationship between taurine levels and approximately 50 health parameters in 12,000 European adults aged 60 and over. The researchers do not know yet if taurine supplements will improve health or increase longevity in humans, but two experiments they conducted suggest taurine has potential. Taurine prevented weight gain, reduced fasting blood glucose and markers of liver damage, increased bone density in the spine and legs, and improved the health of their immune systems. Similar health effects of taurine supplements were seen in middle-aged rhesus monkeys, which were given daily taurine supplements for six months. Credit: Columbia University Irving Medical CenterĪt a cellular level, taurine improved many functions that usually decline with age: The supplement decreased the number of "zombie cells" (old cells that should die but instead linger and release harmful substances), increased survival after telomerase deficiency, increased the number of stem cells present in some tissues (which can help tissues heal after injury), improved the performance of mitochondria, reduced DNA damage, and improved the cells' ability to sense nutrients. "Not only did we find that the animals lived longer, we also found that they're living healthier lives," Yadav says.Ī bout of exercise increases taurine levels. The researchers found that taurine suppressed age-associated weight gain in female mice (even in "menopausal" mice), increased energy expenditure, increased bone mass, improved muscle endurance and strength, reduced depression-like and anxious behaviors, reduced insulin resistance, and promoted a younger-looking immune system, among other benefits. These experts measured various health parameters in mice and found that at age two (60 in human years), animals supplemented with taurine for one year were healthier in almost every way than their untreated counterparts. To learn how taurine impacted health, Yadav brought in other aging researchers who investigated the effect of taurine supplementation on the health and lifespan in several species. Taurine supplements in middle age improves health in old age Credit: Columbia University Irving Medical Center From here we can also configure a new technology Nimble call “Virtual Target IP addresses” as well as creating “Network Zones” to stop traversing and saturating Inter-Switch Links for Multipath configurations. Nimble has now dedicated “Networking” tab available in the administration menu where the Group or individual arrays can be changed. The network configuration on the array is easily configured. When configuring the array with your ESXi or Windows servers you will use the target IP address shown below to configure your storage connectivity. One of the nice feature in the GUI is when you hover over a port in the array screen it will then highlight which port it corresponds to on the array and display the IP address and status on screen. The compression within the Nimble storage array happens inline with no performance loss and can offer between 30-75 percent saving depending on the workload.Ĭheck out the following page for more information on CASL – Nimble use an architecture called CASL (Cache Accelerated Storage Architecture) This is made up of a number of components, SSDs are utilised as a Random Read Cache for Hot Blocks in utilisation within the systems, random writes are coalesced through NVRAM to the array, and it compresses them and writes them sequentially to the RAID 6 near line SAS spinning disks resulting in write operations that Nimble claim can be up to 100x faster than traditional disk alone. We can see on the screenshot below on a different system that there are a number of shelves configured and that we have active and hot standby controllers configured. The theoretical maximums are thus ~280,000 IOPS & 508TB usable storage in a scale out cluster! Today Nimble supports up to 4 arrays in a group – each array supporting 3 shelves of additional disk. This now forms part of a Nimble Storage array “Group”. Nimble have now released version 2.0 of their software, meaning that scale-out is now available as a third scaling method for any Nimble array. What is different about Nimble is the architecture is not based on drive spindles to deliver performance as like traditional storage arrays, rather using multiple Intel Xeon processors to drive IOPS from the array. You then can increase capacity by attaching up to a further 3 shelves of high-capacity drives using the SAS connectors on the controllers, or you can scale performance by upgrading the controllers or swapping for larger SSDs. Prior to Nimble OS 2.0, the architecture worked with a frame / scale up based design where you start with a head unit that contains 2 controllers, 12 high-capacity spinning disks and a number of high-performance SSDs. Finally on the left we have a breakdown of events over the last 24 hours. In the middle we have a breakdown of throughput in MB/Sec and IOPS broken down by Reads and Writes. On the left we can see a breakdown of the storage usage including snapshots, below this we can see what our space saving is, utilising the in-line compression technology for both primary and snapshot data. The home screen shows you a good overview of what is happening within your storage array. Very recently Nimble have announced Nimble OS 2.0, which this walkthrough is based on and big thanks to Nick for helping me up date this from 1.X to 2.X I sat down with a good friend of mine Nick Dyer around 6 months ago, Nick at the time had been with Nimble for only a few months after previously being at Xsigo and Dell EqualLogic, we discussed who Nimble were and what made them different to everyone else in the market place, Nick also gave me a tour of its features and functionality. This is a blog post that has been long overdue, I have blogged about Nimble Storage a couple of times when at VMworld and Devin Hamilton (Director of Storage Architecture & Nimble’s first ever customer-facing engineer) was also on one of the HandsonVirtualization podcasts that we recorded in the past. The subject sleeps "on a pillow made of concrete" and panhandles passersby for spare change. The stark lyrics by Vedder for "Even Flow" describe the experience of being a homeless man. The vocal line that appears in the main verse begins with a very prominent tritone interval. I tried to steal everything I know from Stevie Ray Vaughan and put it into that song. I just followed him in a regular pattern. Stone (Gossard, Pearl Jam guitarist) wrote the riff and song I think it's a D tuning. That's me pretending to be Stevie Ray Vaughan, and a feeble attempt at that. The song features a funk guitar riff by Gossard. The recorded version of the song actually sounds slightly sharper than D major, with everything tuned up - accidentally or otherwise - around one quarter of a step. "Even Flow" was written in the key of D major, with Gossard performing his parts in open D tuning and McCready complementing it with a similar rhythm pattern in standard tuning. This version is on Pearl Jam's 2004 greatest hits album, rearviewmirror (Greatest Hits 1991–2003). This version was used for the music video, and was used in single releases in the United Kingdom. I still don't think Stone is satisfied with how it came out." Īn alternate version of the song was recorded with drummer Dave Abbruzzese in 1992 while the band was recording songs for the soundtrack for the 1992 film, Singles. We played that thing over and over until we hated each other. Not sure why we didn't use that one from the demo as well, but I know it felt better." Guitarist Mike McCready stated, "We did 'Even Flow' about 50, 70 times. There were a hundred takes on that song, and we just never nailed it." Drummer Dave Krusen said, "I was pretty green back then and 'Even Flow' suffered from too much fluctuation." He added that "it was really tough for me. Bassist Jeff Ament said, "I knew it was a great song all along, and I felt that it was the best song that we got the worst take of on the first record. "Even Flow" features lyrics written by vocalist Eddie Vedder and music written by guitarist Stone Gossard. A remixed version of the song was included on the 2009 Ten reissue. The song was included in Pearl Jam's 2004 greatest hits album, rearviewmirror (Greatest Hits 1991–2003). The song peaked at number three on the Billboard Mainstream Rock Tracks chart. Featuring lyrics written by vocalist Eddie Vedder and music written by guitarist Stone Gossard, it was released in 1992 as the second single from the band's debut album, Ten (1991). " Even Flow" is a song by the American rock band Pearl Jam. You can also round to the nearest half, one-fourth, or one-eighth. They require you to enter at least two fractions for benchmark fraction calculation. Several benchmark fraction calculators are available online. Now, we will consider the two fractions on a benchmark fraction chart. The following example will help you understand using a benchmark fraction chart for comparing two fractions. The process is similar to using fraction strips for estimations. We have to consider the length of the corresponding fractions and draw conclusions. It is simple to use a benchmark chart to compare two or more fractions. Students can move these strips, put them side by side, and study fractional amounts. They help students see how different equal parts can represent a whole. These strips have several benchmark fractions marked on them that enable students to develop a concrete understanding of equivalent fractions, mixed numbers, comparing, and ordering fractions. They are also called fraction bars or fraction tiles.Ĭolored fraction strips make it interesting for students to explore and visualize fraction relationships. Fraction Strips with Benchmark Fractionsįraction strips are colored pieces of paper, similar in length, containing benchmark fractions. Thus, from the number line, we can conclude that 5/12 is greater than ¼. Here 0/12 represents zero, 6/12 is for ½, and 12/12 is 1. We can use it to compare fractions.Įxample: Compare which fraction is greater: ¼ or 5/12.įirst, we will draw a number line to compare the two fractions, as shown below. How to Compare Fractions by using Benchmarks and Number Lines?Ī number line is the most commonly used visual representation of fractions. Measuring tape several carpentry and construction tools Measuring spoons and cups have several benchmark fractions marked on them. Real-life examples of benchmark fractions: A ruler used in everyday life has halves, fourths, and eighths as benchmark fractions. Here we must multiply both the numerator and denominator with the same number. Since there are six multiples involved in reaching up to 12 in the denominator, we will multiply ½ by 6 as follows: We will stop when we get the denominator of the other number. We will first make a list of multiples of 2 (the denominator of ½). As three is less than four, 3/8 will be slightly less than one-half.Įxample: Compare ½ and 7/12 to see which one is greater. How to Compare Fractions using Benchmark Fractions?Ĭonsider the following examples to understand how to compare different fractions with benchmark fractions.Įxample: Compare whether 3/8 is less or more than one-half? Some common benchmark fraction examples are as follows: Therefore, it is much closer to 5/10 (or ½) than 0 or 1. So, on comparing 4/10 to 5/10, we can note that it is only 1/10 away from 5/10. So, a fraction with ten as the denominator can be compared to 5/10 as we know that it is exactly half. 5/10 is equivalent to ½ on simplification. If we use 1/2 as a benchmark fraction, it simplifies the process. If the numerator is exactly half the amount of the denominator, then the fraction is equivalent to one-half. We will first study the numerator and compare it to the denominator. Now, we can compare the other fractions with different denominators to one half.Īlso, it is simple to determine whether a fraction is equivalent to one-half. ½ can also be written in different forms or equivalent fractions, such as 2/4, 3/6, 4/8, and so on. It lies right in the middle between zero and one. Therefore, the most common benchmark fraction example is ½ (one-half). We can easily divide any object to be measured or compared into two equal parts. Using benchmark fractions for estimations helps students develop fraction number sense and advance their mental math skills. They are simple common fractions that each of us is familiar with, and they make visualizing complicated fractions much easier. So, a known size or amount helps understand a different size or amount. How to compare fractions by using benchmarks and number lines?īenchmark fraction definition: A common fraction that we can use to compare other fractions is a benchmark fraction.How to compare fractions using benchmark fractions?.The word benchmark refers to a standard that other things can be compared to. Their role and usage are the same as their name suggests. Want to simplify comparing and ordering fractions? Learn all about benchmark fractions, their definition, use, chart, and much more, as it is one of the best strategies to use these fractions when understanding the comparison of fractions. 2/12 or 6/7- which one is greater? To answer this, one would have to calculate the lowest common denominator and then multiply both fractions so that they share a common denominator and then compare them. Your daughter holds the prized train up high over her head, well out of reach from little hands, and continues to scream.īoth of your children are now crying, and your anger hits a boiling point. You watch on helplessly from about five feet away as your son topples to his side and begins to wail. She wants the choo-choo train her baby brother is holding, despite the basket of toy trains that sit on the floor right next to her.Īll too fast, your daughter’s flailing arms kick a pillow off the couch and, womp, the pillow lands smack dab onto baby brother's head. When we heal ourselves, we can heal the world.Your four-year-old daughter drops to the floor in a puddle, arms and legs flailing. If this resonates with you, definitely check Generation Mindful out. And the future will need healthy, well-adjusted leaders perhaps more than ever. We are literally creating the next generation and molding the future in terms of how we nurture that generation's development. It's a beautiful thing to consciously change generational patterns, and I'm profoundly grateful for the support and resources available to parents today to do so. I'm also incredibly grateful to have a partner who is on board and fully engaged with me in this emotional intelligence adventure. A couple of sayings that I’ve already picked up from our Positive Parenting course that I love are “name it to tame it” and “feel it to heal it”. When we shut down or reject our feelings (or the feelings of others), that’s when problems fester and the pressure builds to create acting-out behaviors and conflicts. One thing that I’ve really internalized as a coach is the power of active listening, validation, compassion, and non-judgment. I'm truly grateful and excited to explore this parenting approach with Isaac and to give him a start in life that is light years ahead of some of what I experienced as a kid (spanking, "stop crying", etc). It's going to take us some time to fully digest, integrate and implement all of the valuable knowledge and skills! We just started an after-breakfast morning ritual of reading one “Peacemaker” card per day to help us consider ideas like what it means to be a leader, the importance of sticking with things and getting things done, what love is, why kindness matters, the power of play, and so much more. There is so much to explore, so much juicy content with the "Time In Tool Kit", the Positive Parenting course, and everything that Generation Mindful offers. I love that there are illustrations to help Isaac identify his feelings, games to play to make exploring these topics fun, and that all of this encourages and cultivates connection between all of us. It's a work in progress, but I am loving putting this sacred space together for him (I'm going with a "magical forest" theme) and bit by bit we’re learning to use all of the tools and resources Generation Mindful provides. We also ordered supplies to create a "Calming Corner" for Isaac, a safe place for him to calm down whenever he's feeling overwhelmed. The course advocates for love-based, shame-free discipline versus punishment and power struggles. John and I are currently taking the Generation Mindful Positive Parenting course, which teaches parents how to recognize their own triggers and regulate their own emotions so that they can more effectively teach their children emotion regulation and cultivate emotional intelligence amongst everyone in the family. Isaac is enamored of his "Snuggle Buddies" - stuffed animals meant to bring him comfort and also to help him learn about and understand his emotions. My husband and I have recently become raving fans (and clearly so has our son) of Generation Mindful. If you find yourself replacing trimmer line frequently, try using fresh round line-square and star-shaped lines tend to wear faster. If your line is more than 5 years old and breaks often, replace it. Old cutting line can become brittle and prone to breaking. And ease off on the throttle to properly control the speed of the cutting head, especially when cutting against hard surfaces. Instead, slide the cutting head slowly toward the cutting area so you use the tip of the cutting line. To preserve cutting line when cutting thick weeds or against hard surfaces, don't crowd the trimmer head into the area you're cutting. It's normal for the cutting line to wear down as you use it, but the trimmer line can wear faster than you expect if you're cutting tough or thick weeds, if you're cutting against hard surfaces such as rocks and walls, or if the line is spinning too fast. For step-by-step instructions for common repairs, see our repair guides for grass line trimmers. Here are three common problems with the cutting line in line trimmers and what to do about them.įor additional and more specific information, refer to the owner's manual that came with your trimmer. But problems with the cutting line can make the trimming job frustrating. Grass line trimmers-also called string trimmers-are a great lawn and garden tool for cutting grass and weeds where the mower can't reach, and for edging next to pavement. Investors can utilize Altman Z-scores to decide if they ought to buy or sell a stock on the off chance that they're worried about the company's underlying financial strength.
Genomic classification has been a gauge for clinical management of melanoma patients by using immunotherapy or targeted inhibitors of BRAF V600 and MEK1/2. Our study indicates that 17-aminogeldanamycin takes several advantages compared with other HSP90-targeting compounds, and can complement activity of BRAF/MEK inhibitors in melanoma cells of different genetic subtypes. As trametinib and vemurafenib did not significantly affect HSP70 and GRP78 transcript levels, cooperation of MEK/BRAF V600E inhibitors and 17-aminogeldanamycin might result from a concurrent inhibition of the RAS/RAF/MEK/ERK cascade and IRE1α-dependent signaling, and cell-intrinsic ER homeostasis can determine the extent of the drug cooperation. In addition, 17-aminogeldanamycin acted cooperatively with trametinib (an inhibitor of MEK1/2) and vemurafenib (an inhibitor of BRAF V600E) in induction of apoptosis in melanoma cell lines as evidenced by in-cell caspase-3/7 activation and PARP cleavage that occurred earlier compared with either drug used alone. 17-aminogeldanamycin exhibited similar activity in NRAS Q61R melanoma cells that harbored a heterozygous inactivating variant of NAD(P)H:quinone oxidoreductase 1 (NQO1 P187S). This might result from an inframe deletion in EIF2AK3 leading to a PERK L21del variant revealed by whole-exome sequencing in melanoma cell lines. Concomitantly, ATF6/p50 level and expression of PERK-dependent genes, CHOP and BIM, remained unaltered. 17-aminogeldanamycin alleviated self-triggered compensatory increase in HSP70 mRNA level and induced endoplasmic reticulum (ER) stress, which was followed by selective diminution of cytoprotective IRE1α-XBP1s pathway activity of unfolded protein response (UPR), inhibition of ERK1/2 activity and induction of apoptosis. Here, we reported that 17-aminogeldanamycin more potently activated caspase-3/7 in BRAF V600E melanoma cells than geldanamycin, another inhibitor of heat shock protein 90 (HSP90). Outcomes of melanoma patient treatment remain unsatisfactory despite accessibility of oncoprotein-targeting drugs and immunotherapy. Tap the buttons to choose any extended keys you want to use. On an iPhone, the list of extended keys appears after you choose Keyboard Options. On an iPad, choose Extended Keys to view the available keys. You can choose which keys you want for your keyboard for more functions. This option is on by default.Įxtended Keys lets you use more keys within your session than the default iOS keyboard has. On an iPad, tap Automatic Keyboard to ensure that the keyboard appears onscreen any time within a session when a keyboard is needed. Tap Use Unicode Keyboard to use a standard Unicode keyboard. This option is available only while using External Display mode. To do this action, tap Presentation Mode while in External Display mode. While using your iOS device with an external display, you can use your iOS device as a trackpad to control your session. After setting it up, tap External Display to push your session to the external display. This requires specific hardware or devices that support Apple Play. You also can display your session on an external display. The maximum custom resolution is the maximum resolution your iPad supports. On an iPad, you can also enter a custom resolution for your session. On an iPhone, you can also choose Auto-fit Screen. On an iPhone, the options are Small, Medium, and Large. Tap Display Options and choose between Auto-fit Low, Auto-fit Medium, and Auto-fit High. There are several options to configure your resolution for apps and desktops. On an iPhone, tap Settings on the bottom menu. To access the Settings menu, tap the gear icon in the top-right corner on an iPad. Questo articolo è stato tradotto automaticamente. (Aviso legal)Įste artigo foi traduzido automaticamente. (Clause de non responsabilité)Įste artículo ha sido traducido automáticamente. (Haftungsausschluss)Ĭe article a été traduit automatiquement. This article has been machine translated.ĭieser Artikel wurde maschinell übersetzt. Questo contenuto è stato tradotto dinamicamente con traduzione automatica. (Aviso legal)Įste texto foi traduzido automaticamente. (Clause de non responsabilité)Įste artículo lo ha traducido una máquina de forma dinámica. (Haftungsausschluss)Ĭet article a été traduit automatiquement de manière dynamique. This content has been machine translated dynamically.ĭieser Inhalt ist eine maschinelle Übersetzung, die dynamisch erstellt wurde. |
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